Specialist – Bioanalysis

Job Description

Job Description: Specialist – Bioanalysis (In Vitro DMPK)

Position: Specialist – Bioanalysis (In Vitro DMPK)
Location: Bengaluru, Karnataka
Department: Drug Metabolism & Pharmacokinetics (DMPK) / ADME Sciences
Experience: 8–15 Years
Qualification: M.Pharm
Industry: Pharmaceutical / CRO / Drug Discovery Research

Job Summary

We are seeking an experienced Specialist – Bioanalysis (In Vitro DMPK) to serve as the technical expert for bioanalytical activities supporting drug discovery and development programs. The candidate will be responsible for planning, executing, analyzing, and reporting in vitro ADME studies while ensuring high-quality, accurate, and timely data delivery.

This role requires deep expertise in LC-MS/MS-based bioanalysis, in vitro ADME assays, metabolite identification, and physicochemical profiling, along with the ability to mentor junior scientists and optimize laboratory workflows.

Key Responsibilities
LC-MS/MS Expertise
Act as the Subject Matter Expert (SME) for LC-MS/MS-based bioanalytical activities.
Perform operation, maintenance, calibration, and advanced troubleshooting of LC-MS/MS instruments.
Ensure optimal instrument performance and data integrity.
Develop and optimize analytical methods for ADME studies.
In Vitro ADME Assays

Plan, execute, and interpret results from various in vitro ADME studies, including:

Permeability Studies
Caco-2 permeability assays
MDCK permeability assays
PAMPA (Parallel Artificial Membrane Permeability Assay)
Metabolic Stability Studies
Hepatocyte stability assays
Microsomal stability assays
CYP inhibition studies
Drug metabolism investigations
Physicochemical & Stability Studies
High-throughput solubility assessments
Plasma stability studies
Buffer stability evaluations
Simulated Gastric Fluid (SGF) stability
Simulated Intestinal Fluid (SIF) stability
Physicochemical Profiling

Lead execution and interpretation of:

Kinetic Solubility Studies
Thermodynamic Solubility Studies
Chromatographic Log D Determination
Metabolite Identification (MET-ID)
Analyze metabolite identification samples using LC-MS/MS.
Interpret metabolite profiles and pathways.
Generate detailed scientific reports and presentations.
Workflow & Project Management
Maintain and optimize bioanalytical project workflows.
Ensure timely completion of studies and project deliverables.
Coordinate with project teams to support drug discovery programs.
Monitor laboratory productivity and improve operational efficiency.
Team Leadership & Mentoring
Train and mentor junior scientists and analysts.
Provide technical guidance on bioanalytical methods and ADME protocols.
Ensure adherence to scientific and laboratory quality standards.
Support continuous learning and development within the team.
Required Qualifications
Education
M.Pharm (Pharmaceutical Analysis, Pharmaceutics, Pharmacology, or related discipline)
Experience
8–15 years of relevant experience in:
Bioanalysis
DMPK
ADME studies
Drug Discovery Research
Experience within Pharmaceutical Companies or CRO environments preferred.
Technical Skills
Essential
Extensive hands-on experience with LC-MS/MS systems.
Strong understanding of ADME and DMPK principles.
Expertise in:
Permeability assays
Metabolic stability assays
CYP inhibition studies
Solubility assessments
Stability studies
Metabolite identification
Preferred
Method development and validation experience.
Data interpretation and scientific reporting.
Laboratory workflow optimization.
Instrument troubleshooting and maintenance.
Key Competencies
Strong analytical and problem-solving abilities.
Scientific report writing skills.
Attention to detail and data accuracy.
Project management and prioritization skills.
Team leadership and mentoring capabilities.
Effective communication and collaboration skills.
Why Join?
Opportunity to work on cutting-edge drug discovery programs.
Exposure to advanced DMPK and ADME technologies.
Leadership and mentoring opportunities.
Collaborative scientific research environment.
Career growth within pharmaceutical and CRO research domains.
Application Details

Position: Specialist – Bioanalysis (In Vitro DMPK)
Location: Bengaluru, Karnataka

Email: krishnafulsure@aurigeneservices.com

Subject Line: Bioanalysis – Invitro DMPK